Oral alendronate, a bisphosphonate, is the first line treatment for Paget disease.
Bisphosphonates. The bisphosphonate class of drugs includes the oral medications alendronate (Fosamax), etidronate (Didronel), risedronate (Actonel), and tiludronate (Skelid). These drugs are the first line of therapy for the treatment of Paget’s disease, and they are also used to pre- vent and treat osteoporosis.
Similarly, is used to treat hypercalcemia osteoporosis and Paget’s disease? Bisphosphonate therapy is a common and effective treatment for Paget’s disease of bone, osteoporosis, hypercalcemia of malignancy and cancer metastatic to bone.
Also Know, what is Paget’s disease quizlet?
Paget’s Disease – define. chronic skeletal bone disorder. excessive bone resorption and then replacement of normal marrow by vascular, fibrous connective tissue. Paget’s Disease – the new bone looks like. larger.
Which of the following is a key feature of Pagets disease?
Paget’s disease frequently causes no symptoms. Paget’s disease can cause pain in the bones or joints, headaches and hearing loss, pressure on nerves, increased head size, bowing of limb, or curvature of spine. Tests used to diagnose Paget’s disease include X-rays, blood tests, and bone scanning.
How does Paget’s disease start?
When Paget’s disease of bone occurs in an area where nerves pass through the bone, such as the spine and skull, the overgrowth of bone can compress and damage the nerve, causing pain, weakness or tingling in an arm or leg or hearing loss.
Which is an early sign of Paget disease?
Signs & Symptoms Additional symptoms may include itching (pruritus) or burning sensations and/or oozing or bleeding of the affected area. Eventually, pain and sensitivity of the affected area may be present. Early on, the skin symptoms of Paget’s disease of the breast may fluctuate, improving only to worsen again.
What are the stages of Paget disease?
The pathogenesis of Paget’s disease is described in four stages: Osteoclastic activity. Mixed osteoclastic – osteoblastic activity. Osteoblastic activity. Malignant degeneration.
What Paget’s disease looks like?
Paget’s disease usually affects the skin of one nipple and produces eczema-like symptoms, appearing as an itchy, red rash on the nipple that can extend to the darker area of surrounding skin (the areola). It can also appear as a small ulcer or dry, red, flaky patches of skin similar to psoriasis.
Is there a blood test for Paget’s disease?
The diagnosis of Paget’s disease may be confirmed by a thorough clinical evaluation, detailed patient history, and a variety of specialized tests, such as blood tests, x-rays, and urine tests. A blood test may reveal elevated levels of the enzyme alkaline phosphatase suggesting the diagnosis of Paget’s disease.
What causes Extramammary Paget’s disease?
The cause of extramammary Paget disease (EMPD) remains unknown. Approximately 25% of cases are associated with an underlying tumor . The type of tumor that is most likely to be associated with this disease is an apocrine carcinoma.
What is the difference between Paget’s disease and osteoporosis?
Paget’s disease is a chronic disorder that can result in enlarged and misshapen bones. Paget’s disease typically is localized, affecting just one or a few bones, as opposed to osteoporosis, for example, which affects all the bones in the body. Scientists do not know for sure what causes Paget’s disease.
What is the prognosis for Paget disease?
The outlook for people diagnosed with Paget’s disease is generally good, particularly if treatment is given before major changes have occurred in the affected bones. Treatment can reduce symptoms but there is no cure.
What is osteoporosis quizlet?
Osteoporosis occurs when bones lose minerals, such as calcium, more quickly than the body can replace them, causing a loss of bone thickness, making the bones brittle and easy to break. You just studied 5 terms!
How do you rule out Paget’s disease?
Methods used to diagnose Paget’s disease. Three tests – an x-ray, blood test, and bone scan – are commonly used to discover Paget’s disease. Sometimes the disease is found by accident when one of these tests is done for another reason. X-rays are used to make the final diagnosis.
Can Pagets disease be cured?
There’s currently no cure for Paget’s disease of bone, but treatment can help relieve the symptoms. If you do not have any symptoms, your doctor may suggest keeping an eye on your condition and delaying treatment until any problems occur.
Is Paget’s disease an autoimmune disease?
Although infrequent, this combination suggests the involvement of common pathogenic mechanisms: thyroiditis and Paget’s disease may stem from the same viral infection and/or autoimmune disorder, whereas chondrocalcinosis may be the consequence of thyroiditis-related hypothyroidism.
Who manages Paget’s disease?
Doctors who are the most experienced in treating patients with Paget’s disease are: Endocrinologists, who treat hormonal and metabolic disorders. Rheumatologists, who treat joint and muscle disorders.
What is the most common age for males and females to be diagnosed with Paget’s disease?
Paget’s disease of the nipple is more common in women, but like other forms of breast cancer, it can also affect men. The disease usually develops after age 50. According to the National Cancer Institute, the average age of diagnosis in women is 62, and in men, 69.